![]() ![]() pneumoniae positive CAD patients, 11(12%) were IgA positive, 13(14.2%) were IgA+IgG positive and only1 (1.1%) was IgG positive. pneumoniae specific IgA, IgA+IgG and IgG antibodies. Positive nPCR patients were compared with presence of C. The sensitivity and specificity of semi-nested and multiplex PCR were 37.03%, 96.96% and 22.22%, 100% with respect to nested PCR. ResultsĢ9.67% (27/91) patients were positive for C. pneumoniae specific IgG and IgA antibodies. nested -, semi-nested – and multiplex PCR were used for detection of C. Venous blood was obtained from 91 CAD patients and 46 healthy controls. This will help in order to prepare strategies for the antibiotic intervention to avoid the progression towards CAD. pneumoniae specific IgA and IgG antibodies, which may indicative of the status of infection with the progression of atherosclerosis. ![]() pneumoniae in blood of CAD patients with C. Further correlation of the presence of C. pneumoniae in circulating blood of coronary artery disease (CAD) patients by sensitive nucleic acid amplification tests nested PCR (nPCR), multiplex PCR (mPCR) has not been carried out is required. pneumoniae specific antibodies in coronary heart disease patients, direct detection of C. Nucleic Acid Amplification tests (NAATs) has emerged as an important method for detecting C. pneumoniae infections, which are especially persistent infections, have been difficult to diagnose either by serological methods or isolation of the organism from the tissue. There is growing evidence that Chlamydia pneumoniae may be involved in the pathogenesis of atherosclerosis, as several studies have demonstrated the presence of the organism in atherosclerotic lesions.
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